Megamasers and Galaxies Fred Lo Institute of Astronomy & Astrophysics Academia Sinica Abstract: While masers on Earth required invention in the 50's, OH and H_2O maser emissions are commonly found in high density and high temperature gas near young stellar objects or evolved stars in our Galaxy. Very powerful extragalactic OH and H_2O masers (mega-masers) are found in nuclei of galaxies, in the molecular media in the immediate vicinity of AGN's and in star-burst regions. In particular, high resolution imaging of the H_2O mega-maser in NGC 4258 led to the first direct delineation of a thin Keplerian accretion disk around a massive compact object. Because of their high luminosity and brightness, mega-masers are important for sub-parsec to parsec scales probes of the molecular media around AGN's and star-burst regions at large distances. They could also be very useful probes of young galaxies at high redshifts