Consequences of massive star feedback in star-forming galaxies Sally Oey Lowell Observatory Populations of massive stars are a principal driver of galaxy evolution. The three dominant effects are: 1. Ionizing radiation, 2. Mechanical feedback, and 3. Chemical enrichment. I will present a self-consistent semi-analytic investigation of the global consequences of these three mechanisms on the interstellar medium of star-forming galaxies, including implications for their evolution.