Quantitative spectroscopy of supergiants Norbert Przybilla IfA Blue supergiants are the visually brightest stars in galaxies. Quantitative spectroscopy of these objects can now be performed at distances well beyond the Local Group using large telescopes and modern instrumentation. An overview is given on recent improvements in the NLTE analysis techniques and their testing on high-resolution, high-S/N data of objects in the Milky Way. First applications to supergiants in other Local Group galaxies and beyond, in NGC300 and NGC3621, are outlined, indicating a large potential for constraining massive star evolution, galactic chemical evolution and the extragalactic distance scale.